师资队伍
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金建明 来源:天博国际app    阅读次数:  2020-08-06

 

通讯地址:北京市海淀区阜成路11

   北京工商大学化学与材料学院

邮编:100048

电话:010-68984937

电子信箱:jinjianming@btbu.edu.cn

工作经历:

2012年至今  北京工商大学理学院 教授

2011-2012 云南民族大学化学与生物技术学院 教授;

2010-2011 美国奥克拉荷马大学 从事研究工作;

2009-2010 香港浸会大学生物系 从事研究工作;

2002-2009 韩国首尔大学农学与生命科学学院 从事研究工作;

1997-1999 中国科学院水生生物研究所 助理研究员;

1993-1994 浙江永宁药业股份有限公司。

学历:

1999-2002 中国科学院昆明植物研究所植物化学专业,获理学博士学位;

1994-1997 武汉大学生命科学学院生物化学专业,获理学硕士学位;

1989-1993 武汉大学生命科学学院生物化学专业,获理学学士学位。

讲授课程:

天然产物化学;天然产物分离工程。

研究领域:

1、           中草药提取物的精制和开发应用研究;

2、           天然活性成分的高效生物转化研究;

3、           天然活性成分的生物合成及其调控机制研究。

科研项目:

主持2项国家自然科学基金和1项北京市自然科学基金项目,参与1项科技部科技支撑项目和1项星火项目,与多个企业合作进行新产品研发和生产技术改造。

 

发表论文:

1.    Jun Yao#, Yang He#, Nannan Su, Sakshibeedu R. Bharath, Yong Tao, Jian-Ming Jin*, Wei Chen*, Haiwei Song* and Shuang-Yan Tang*. Developing a highly efficient hydroxytyrosol whole-cell catalyst by de-bottlenecking rate-limiting steps. Nature Communications, 2020, 11: 1515.

2.    Jun Yao#, Jing Li#, Dandan Xiong, Yuanyuan Qiu, Guizhi Shi, Jian-Ming Jin*, Yong Tao* and Shuang-Yan Tang*. Development of a highly efficient and specific L-theanine synthase. Applied Microbiology and Biotechnology, 2020, 140(8): 3417-3431.

3.    Chaoning Liang, Xuanxuan Zhang, Jieyuan Wuc, Shanshan Mu, Zhe Wu, Jian-Ming Jin* and Shuang-Yan Tang*. Dynamic control of toxic natural product biosynthesis by an artificial regulatory circuit. Metabolic Engineering, 2020, 57: 239-246.

4.    Wei Chen#, Jun Yao#, Jie Meng, Wenjing Han, Yong Tao, Yihua Chen, Yixin Guo, Guizhi Shi, Yang He, Jian-Ming Jin* and Shuang-Yan Tang*. Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis. Nature Communications, 2019, 10: 960.

5.    Chen Wei, Zhang Xuanxuan, Xiong Dandan, Jin Jian-Ming* and Tang Shuang-Yan*. Engineering the effector specificity of regulatory proteins for the in vitro detection of biomarkers and pesticide residues. Applied Microbiology and Biotechnology, 2019, 103(7): 3205–3213.

6.      Heng Li, Jing Li, Ruinan Jin, Wei Chen, Chaoning Liang, Jieyuan Wu, Jian-Ming Jin, Shuang-Yan Tang*. Towards the construction of high-quality mutagenesis libraries. Biotechnology Letter, 2018, 40: 1101–1107.

7.      Heng Li, Wei Chen, Rui-Nan Jin, Jian-Ming Jin*, Shuang-Yan Tang*. Biosensor‑aided high‑throughput screening of hyper‑producing cells for malonyl‑CoA‑derived products. Microbial Cell Factories, 2017, 16: 187.

8.      Heng Li, Chaoning Liang, Wei Chen, Jian-Ming Jin*, Shuang-Yan Tang*, Yong Tao. Monitoring in vivo metabolic flux with a designed whole-cell metabolite biosensor of shikimic acid. Biosensors and Bioelectronics, 2017, 98: 457–465.

9.      Jieyuan Wu, Peixia Jiang, Wei Chen, Dandan Xiong, Linglan Huang, Junying Jia, Yuanyuan Chen, Jian-Ming Jin*, Shuang-Yan Tang*. Design and application of a lactulose biosensor. Scientific Reports, 2017, 7: 45994.

10.   Dandan Xiong, Shikun Lua, Jieyuan Wu, Chaoning Liang, Wei Wang, Wenzhao Wang, Jian-Ming Jin*, Shuang-Yan Tang*. Improving key enzyme activity in phenylpropanoid pathway with a designed biosensor. Metabolic Engineering, 2017, 40: 115-123.

11.   You-Hai Li, Wen-Jin Han, Xi-Wu Gui, Tao Wei, Shuang-Yan Tang, Jian-Ming Jin*. Putative nonribosomal peptide synthetase and cytochrome P450 genes responsible for tentoxin biosynthesis in Alternaria alternata ZJ33. Toxins, 2016, 8: 234.

12.   Chaoning Liang, Yi Zhang, Yan Jia, Wenzhao Wang, Youhai Li, Shikun Lu, Jian-Ming Jin*, Shuang-Yan Tang*. Engineering a carbohydrate-processing transglycosidase into glycosyltransferase for natural product glycodiversification. Scientific Reports, 2016, 6: 21051.

13.   Lin Zhu, Zhe Wu, Jian-Ming Jin, Shuang-Yan Tang*. Directed evolution of leucine dehydrogenase for improved efficiency of l-tert-leucine synthesis. Applied Microbiology and Biotechnology, 2016, 100: 5805-5813.

14. 文海丽,许丽,李有海,韩文敬,金建明*。三七总皂苷酶水解产物成分研究。天然产物研究与开发,2018301565-1568

15. 韩文敬,陆仕坤,文海丽,许丽,金建明*,唐双焱。人参果梗的化学成分研究。中草药,201849(8): 1571-1580

 

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